Sulindac sulfide

• Catalog No.: S3131
• CAS Number: 32004-67-4
• M. F.: C20H17FO2S
• M. W.: 340.4111832
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-[(1Z)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
• IUPAC Traditional name: [(3Z)-6-fluoro-2-methyl-3-{[4-(methylsulfanyl)phenyl]methylidene}inden-1-yl]acetic acid
• Synonyms: (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

DATABASE IDS

• MDL Number: MFCD00869764
• CAS Number: 32004-67-4
• EC Number: 250-892-2
• PubChem SID: 24899543

PROPERTIES

• Purity: ≥98% (HPLC)
• Apperance: yellow solid
• Solubility: DMSO: ≥22 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H317-H334-H361
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 63-22-42/43
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism.