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Sulindac sulfide_Molecular_structure_CAS_32004-67-4)
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Sulindac sulfide

Catalog No. S3131 Name Sigma Aldrich
CAS Number 32004-67-4 Website http://www.sigmaaldrich.com
M. F. C20H17FO2S Telephone 1-800-521-8956
M. W. 340.4111832 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 132926

SYNONYMS

IUPAC name
2-[(1Z)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
IUPAC Traditional name
[(3Z)-6-fluoro-2-methyl-3-{[4-(methylsulfanyl)phenyl]methylidene}inden-1-yl]acetic acid
Synonyms
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

DATABASE IDS

MDL Number MFCD00869764
CAS Number 32004-67-4
EC Number 250-892-2
PubChem SID 24899543

PROPERTIES

Purity ≥98% (HPLC)
Apperance yellow solid
Solubility DMSO: ≥22 mg/mL
GHS Pictograms GHS07
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H302-H317-H334-H361
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P261-P280-P342 + P311
Risk Statements 63-22-42/43
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism.

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