Rapamycin from Streptomyces hygroscopicus

• Catalog No.: R0395
• CAS Number: 53123-88-9
• M. F.: C51H79NO13
• M. W.: 914.17186
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• IUPAC Traditional name: (1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• Synonyms: 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; Sirolimus; AY 22989

DATABASE IDS

• PubChem SID: 24899339
• MDL Number: MFCD00867594
• CAS Number: 53123-88-9

PROPERTIES

• Solubility: ethanol: soluble2 mM
• Solubility: DMSO: soluble
• Apperance: off-white powder
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: VE6250000
• Storage Temperature: -20°C
• German water hazard class: 2
• Purity: ≥95% (HPLC)
• Quality Level: PREMIUM
• Gene Information: human ... FKBP1A(2280)

DETAILS

Description (English)

Frequently Asked Questions
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Biochem/physiol Actions
A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information