8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt

• Catalog No.: B1381
• CAS Number: 51116-01-9
• M. F.: C10H10BrN5NaO7P
• M. W.: 446.083231
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-6,9-dihydro-1H-purin-9-yl)-7-hydroxy-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• IUPAC Traditional name: sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1H-purin-9-yl)-7-hydroxy-2-oxo-tetrahydro-4H-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• Synonyms: 8-Br-cGMP; 8-Bromo-cyclic GMP

DATABASE IDS

• PubChem SID: 24278021
• CAS Number: 51116-01-9
• MDL Number: MFCD00070128
• EC Number: 256-993-8

PROPERTIES

• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: H2O: soluble50 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase. Slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine. Reported to mimic the effect of nitric oxide generating drugs.