Kanamycin disulfate salt from Streptomyces kanamyceticus

• Catalog No.: K1876
• CAS Number: 64013-70-3
• M. F.: C18H40N4O19S2
• M. W.: 680.6556

SYNONYMS

• Title: Kanamycin 二硫酸盐 来源于卡那霉素链霉菌
• IUPAC name: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol; bis(sulfuric acid)
• IUPAC Traditional name: kanamycin; bis(sulfuric acid)
• Synonyms: Kanamycin 硫酸氢盐; Kanamycin A

DATABASE IDS

• MDL Number: MFCD00143916
• CAS Number: 64013-70-3

PROPERTIES

• Impurities: ≤4% Kanamycin B
• Potency: ~650 μg per mg
• GHS Signal Word: Danger
• GHS Hazard statements: H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 61
• Safety Statements: 53-45
• German water hazard class: 3

DETAILS

Description (English)

Preparation Note
Kanamycin acid sulfate is prepared by solubilizing kanamycin sulfate in dilute sulfuric acid and drying. The sulfate content is approximately 25%.
Application
Aminoglycoside-antibiotic with broad antibacterial spectrum, (including mycobacteria, many gram-positive and most gram-negative organisms); Additive in culture media for the isolation of group D Streptococci on Kanamycin Esculin Azide Agar (Mossel et al.) or for selection of transformed plant cells containing the neomycin phosphotransferase (for kanamycin resistance); on a kanamycin-medium1,2. Kanamycin has been used for electrophysiological recordings of outer hair cells and inner hair cells3. It is used to inhibit shoot regeneration from Siberian Elmleaf explants4.
Biochem/physiol Actions
Kanamycin inhibits shoot regeneration of Siberian Elm leaf explants4. Kanamycin is an aminoglycoside antibiotic. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasm.