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Trichostatin A_Molecular_structure_CAS_58880-19-6)
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Trichostatin A

Catalog No. T8552 Name Sigma Aldrich
CAS Number 58880-19-6 Website http://www.sigmaaldrich.com
M. F. C17H22N2O3 Telephone 1-800-521-8956
M. W. 302.36818 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 3905


IUPAC name
IUPAC Traditional name
trichostatin a


CAS Number 58880-19-6
MDL Number MFCD03848392
PubChem SID 24900542


Gene Information human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)mouse ... ENSMUSG00000061062(15181)rat ... Hdac7a(84582)
Solubility ethanol: soluble2 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H312-H315-H317-H319-H332-H335
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P261-P280-P305 + P351 + P338
Risk Statements 20/21/22-36/37/38-43
RTECS MI5215000
Safety Statements 26-36
Storage Temperature -20°C
German water hazard class 3
Biological Source from Streptomyces sp.
Purity ≥98% (HPLC)
Quality Level PREMIUM


Description (English)
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Biochem/physiol Actions
Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.