Trichostatin A

• Catalog No.: T8552
• CAS Number: 58880-19-6
• M. F.: C17H22N2O3
• M. W.: 302.36818
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
• IUPAC Traditional name: trichostatin a
• Synonyms: TSA; [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

DATABASE IDS

• CAS Number: 58880-19-6
• MDL Number: MFCD03848392
• PubChem SID: 24900542

PROPERTIES

• Gene Information: human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)mouse ... ENSMUSG00000061062(15181)rat ... Hdac7a(84582)
• Solubility: ethanol: soluble2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H315-H317-H319-H332-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 20/21/22-36/37/38-43
• RTECS: MI5215000
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3
• Biological Source: from Streptomyces sp.
• Purity: ≥98% (HPLC)
• Quality Level: PREMIUM

DETAILS

Description (English)

Frequently Asked Questions
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Biochem/physiol Actions
Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.