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Leupeptin hydrochloride_Molecular_structure_CAS_24125-16-4)
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Leupeptin hydrochloride

Catalog No. L0649 Name Sigma Aldrich
CAS Number 24125-16-4 Website http://www.sigmaaldrich.com
M. F. C20H39ClN6O4 Telephone 1-800-521-8956
M. W. 463.01446 Fax
Purity ≥70% (HPLC) Email
Storage Chembase ID: 105990


亮抑酶肽 盐酸盐
IUPAC name
N-(5-carbamimidamido-1-oxopentan-2-yl)-2-(2-acetamido-4-methylpentanamido)-4-methylpentanamide hydrochloride
IUPAC Traditional name
N-(5-carbamimidamido-1-oxopentan-2-yl)-2-(2-acetamido-4-methylpentanamido)-4-methylpentanamide hydrochloride
Acetyl-Leu-Leu-Arg-al 盐酸盐


CAS Number 24125-16-4
PubChem SID 24896263
MDL Number MFCD00133457


Biological Source microbial
Purity ≥70% (HPLC)
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature -20°C
German water hazard class 3


Description (简体中文)
Analysis Note
由于三种形式在溶液中达到平衡,亮抑酶肽可在 HPLC 上形成多个峰。通过三个主峰测定纯度。主要的杂质肽为外消旋亮抑酶肽。
Biochem/physiol Actions
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin.1 (Loss of cochlear hair cells is believed to be mediated by calpain.)