Atrial Natriuretic Peptide human

• Catalog No.: A1663
• CAS Number: 91917-63-4
• M. F.: C127H205N45O39S3
• M. W.: 3082.4597
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: 3-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-amino-3-hydroxypropanamido)-4-methylpentanamido]-5-carbamimidamidopentanamido}-5-carbamimidamidopentanamido)-3-hydroxypropanamido]-3-hydroxypropanamido}-3-sulfanylpropanamido)-3-phenylpropanamido]acetamido}acetamido)-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido}-3-({4-carbamimidamido-1-[(1-{[({1-[(1-{[1-({[(1-{[({1-[(1-{[1-({1-[(4-carbamimidamido-1-{[1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-2-carbamoylethyl)carbamoyl]-2-sulfanylethyl}carbamoyl)methyl]carbamoyl}-3-methylbutyl)carbamoyl]methyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl)carbamoyl]ethyl}carbamoyl)methyl]carbamoyl}-2-methylbutyl)carbamoyl]butyl}carbamoyl)propanoic acid
• IUPAC Traditional name: 3-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-amino-3-hydroxypropanamido)-4-methylpentanamido]-5-carbamimidamidopentanamido}-5-carbamimidamidopentanamido)-3-hydroxypropanamido]-3-hydroxypropanamido}-3-sulfanylpropanamido)-3-phenylpropanamido]acetamido}acetamido)-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido}-3-({4-carbamimidamido-1-[(1-{[({1-[(1-{[1-({[(1-{[({1-[(1-{[1-({1-[(4-carbamimidamido-1-{[1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-2-carbamoylethyl)carbamoyl]-2-sulfanylethyl}carbamoyl)methyl]carbamoyl}-3-methylbutyl)carbamoyl]methyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl)carbamoyl]ethyl}carbamoyl)methyl]carbamoyl}-2-methylbutyl)carbamoyl]butyl}carbamoyl)propanoic acid
• Synonyms: hANF; ANF 1-28

DATABASE IDS

• CAS Number: 91917-63-4
• PubChem SID: 24890580
• MDL Number: MFCD00076226

PROPERTIES

• Purity: ≥97% (HPLC)
• Gene Information: human ... NPPA(4878)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7-23]
Biochem/physiol Actions
Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.