L-Mimosine from Koa hoale seeds

• Catalog No.: M0253
• CAS Number: 500-44-7
• M. F.: C8H10N2O4
• M. W.: 198.176
• Purity: ≥98%

SYNONYMS

• IUPAC name: (2S)-2-amino-3-(3-hydroxy-4-oxo-1,4-dihydropyridin-1-yl)propanoic acid
• IUPAC Traditional name: mimosine
• Synonyms: Leucenol; (S)-α-Amino-β-[1-(3-hydroxy-4-oxopyridine)]propionic acid

DATABASE IDS

• MDL Number: MFCD00075909
• CAS Number: 500-44-7
• EC Number: 207-905-1
• PubChem SID: 24896541

PROPERTIES

• Purity: ≥98%
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H332
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22
• Safety Statements: 22-36
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. An iron chelator that inhibits DNA replication in mammalian cells. Has been shown to have apoptotic activity in xenotransplanted human pancreatic cancer. L-Mimosine is also used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). L-Mimosine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.