Erythromycin estolate

• Catalog No.: E8630
• CAS Number: 3521-62-8
• M. F.: C49H93NO17S
• M. W.: 1000.32422

SYNONYMS

• IUPAC name: (3S,4R,5R,6S,7S,9S,12R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione; (dodecyloxy)sulfonic acid
• IUPAC Traditional name: (3S,4R,5R,6S,7S,9S,12R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione N-dodecyl sulfate
• Synonyms: Erythromycin 2′-propionate dodecyl sulfate

DATABASE IDS

• CAS Number: 3521-62-8
• EC Number: 222-532-4
• PubChem SID: 24894679
• MDL Number: MFCD00084691

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H302-H317-H334
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 22-42/43
• Safety Statements: 22-36
• German water hazard class: 3

DETAILS

Description (English)

Application
Erythoromycin estolate is used to study hepatic cytochrome P-450 induction and inactivation via cytochrome-metabolite complex formation1 and Giardia intestinalis inefections2. It is used to study antibiotic cytotoxicity in cultured human liver cell lines3.
Biochem/physiol Actions
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).