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Cinoxacin

Catalog No. C8645 Name Sigma Aldrich
CAS Number 28657-80-9 Website http://www.sigmaaldrich.com
M. F. C12H10N2O5 Telephone 1-800-521-8956
M. W. 262.2182 Fax
Purity Email
Storage Chembase ID: 706

SYNONYMS

IUPAC name
1-ethyl-4-oxo-1H,4H,7H-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
IUPAC Traditional name
cinoxacin

DATABASE IDS

MDL Number MFCD00056776
PubChem SID 24278343
CAS Number 28657-80-9
EC Number 249-133-8

PROPERTIES

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS JI4640000
German water hazard class 2

DETAILS

Description (English)
Application
Cinoxacin is a synthetic antimicrobial commonly used in urinary tract infections that are caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species, and Enterobacter species.. It is a quinolone gyrase inhibitor. It is used to study the rat renal organic anion transporter 1 (OAT1)1. It is used to study fluoroquinolone-resistant Streptococcus pyogenes2.
Biochem/physiol Actions
Cinoxacin interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding. Cinoxacin allows for proper replicated DNA separation. Therefore, the inhibition of Cinoxacin inhibits DNA replication and cell division.
Cinoxacin interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C8645.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

REFERENCES