Cloxacillin sodium salt monohydrate

• Catalog No.: C9393
• CAS Number: 7081-44-9
• M. F.: C19H20ClN3NaO6S
• M. W.: 476.88637

SYNONYMS

• IUPAC name: (2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid hydrate sodium
• IUPAC Traditional name: cloxacillin hydrate sodium

DATABASE IDS

• PubChem SID: 24893156
• MDL Number: MFCD00150735
• CAS Number: 7081-44-9
• EC Number: 211-390-9

PROPERTIES

• Suitability: suitable for 1694 per US EPA
• GHS Signal Word: Danger
• GHS Hazard statements: H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 36/37/38-42/43
• RTECS: XH8920000
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Application
Cloxacillin is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. It is also known as cloxacillin sodium. It is used to treat infections caused by penicillin G-resistant staphylococci1. It has been used in studies of topical antibacterial agent for burn and crush wounds2.
Biochem/physiol Actions
Cloxacillin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin may interfere with autolysin inhibitors. Cloxacillin is used as an AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.
Cloxacillin is used as an AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.