(±)-Miconazole nitrate salt

• Catalog No.: M3512
• CAS Number: 22832-87-7
• M. F.: C18H15Cl4N3O4
• M. W.: 479.1414

SYNONYMS

• IUPAC name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; nitric acid
• IUPAC Traditional name: acid, nitric; miconazole
• Synonyms: 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

DATABASE IDS

• PubChem SID: 24896848
• MDL Number: MFCD00058161
• EC Number: 245-256-6
• CAS Number: 22832-87-7

PROPERTIES

• Suitability: suitable for 1694 per US EPA
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H317
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 22-43
• RTECS: NI4771000
• Safety Statements: 36/37
• German water hazard class: 3

DETAILS

Description (English)

Application
Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. It is used to inhibit cytochrome P450 1 and to study automated luminescence-based cytochrome P450 profiling2.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.