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(±)-Miconazole nitrate salt_Molecular_structure_CAS_22832-87-7)
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(±)-Miconazole nitrate salt

Catalog No. M3512 Name Sigma Aldrich
CAS Number 22832-87-7 Website http://www.sigmaaldrich.com
M. F. C18H15Cl4N3O4 Telephone 1-800-521-8956
M. W. 479.1414 Fax
Purity Email
Storage Chembase ID: 72827

SYNONYMS

IUPAC name
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; nitric acid
IUPAC Traditional name
acid, nitric; miconazole
Synonyms
1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

DATABASE IDS

PubChem SID 24896848
MDL Number MFCD00058161
EC Number 245-256-6
CAS Number 22832-87-7

PROPERTIES

Suitability suitable for 1694 per US EPA
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H317
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P280
Risk Statements 22-43
RTECS NI4771000
Safety Statements 36/37
German water hazard class 3

DETAILS

Description (English)
Application
Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. It is used to inhibit cytochrome P450 1 and to study automated luminescence-based cytochrome P450 profiling2.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

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