Fibrinopeptide A human

• Catalog No.: F3254
• CAS Number: 25422-31-5
• M. F.: C63H97N19O26
• M. W.: 1536.55598
• Purity: ≥96% (HPLC)

SYNONYMS

• Title: Fibrinopeptide A 人类
• IUPAC name: 4-(2-{2-[2-(2-aminopropanamido)-3-carboxypropanamido]-3-hydroxypropanamido}acetamido)-4-({[(1-{[1-({1-[(1-{[1-({[({[({1-[(4-carbamimidamido-1-carboxybutyl)carbamoyl]-2-methylpropyl}carbamoyl)methyl]carbamoyl}methyl)carbamoyl]methyl}carbamoyl)-3-carboxypropyl]carbamoyl}ethyl)carbamoyl]-3-methylbutyl}carbamoyl)-2-phenylethyl]carbamoyl}-2-carboxyethyl)carbamoyl]methyl}carbamoyl)butanoic acid
• IUPAC Traditional name: 4-(2-{2-[2-(2-aminopropanamido)-3-carboxypropanamido]-3-hydroxypropanamido}acetamido)-4-({[(1-{[1-({1-[(1-{[1-({[({[({1-[(4-carbamimidamido-1-carboxybutyl)carbamoyl]-2-methylpropyl}carbamoyl)methyl]carbamoyl}methyl)carbamoyl]methyl}carbamoyl)-3-carboxypropyl]carbamoyl}ethyl)carbamoyl]-3-methylbutyl}carbamoyl)-2-phenylethyl]carbamoyl}-2-carboxyethyl)carbamoyl]methyl}carbamoyl)butanoic acid

DATABASE IDS

• PubChem SID: 24894837
• MDL Number: MFCD00076437
• CAS Number: 25422-31-5

PROPERTIES

• Purity: ≥96% (HPLC)
• Gene Information: human ... FGA(2243)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg
Biochem/physiol Actions
Fibrin polymerization is initiated by thrombin cleavage of fibrinopeptide A from fibrinogen α chains, exposing two E domain E(A) sites. The phenylalanine at α chain residue 8 is important for efficient thrombin-catalyzed proteolysis of fibrinogen. Substitution of tyrosine for phenylalanine blocks sequential fibrinopeptide release and, thus, blocks polymerization and clot formation.