Orotic acid potassium salt

• Catalog No.: O2875
• CAS Number: 24598-73-0
• M. F.: C5H3KN2O4
• M. W.: 194.18662
• Purity: ≥99%

SYNONYMS

• Title: 乳清酸 钾盐
• IUPAC name: potassium 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
• IUPAC Traditional name: potassium orotate
• Synonyms: Uracil-6-carboxylic acid; 6-Carboxy-2,4-dihydroxypyrimidine

DATABASE IDS

• MDL Number: MFCD00039118
• EC Number: 246-341-0
• PubChem SID: 24897970
• CAS Number: 24598-73-0

PROPERTIES

• Purity: ≥99%
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: RM3201500
• German water hazard class: 2

DETAILS

Description (English)

Application
Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.