Tropisetron monohydrochloride

• Catalog No.: T104
• CAS Number: 105826-92-4
• M. F.: C17H21ClN2O2
• M. W.: 320.81384
• Purity: ≥98% (HPLC)

SYNONYMS

• Title: Tropisetron
• IUPAC name: 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1H-indole-3-carboxylate hydrochloride
• IUPAC Traditional name: 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1H-indole-3-carboxylate hydrochloride
• Synonyms: ICS-205,930; 3-Tropanylindole-3-carboxylate monohydrochloride; endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-ol Indol-3-yl-carboxylate 盐酸盐; Navoban

DATABASE IDS

• CAS Number: 105826-92-4
• PubChem SID: 24278133
• MDL Number: MFCD00210221

PROPERTIES

• Purity: ≥98% (HPLC)
• Gene Information: human ... CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)rat ... Chrna7(25302), Drd2(24318), Htr1a(24473), Htr3a(79246)
• Apperance: solid
• Solubility: H2O: >10 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT3 serotonin receptor antagonist.
Tropisetron a selective serotonin 5-HT3 receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.