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4-Hydroxytamoxifen

Catalog No. H6278 Name Sigma Aldrich
CAS Number 68392-35-8 Website http://www.sigmaaldrich.com
M. F. C52H58N2O4 Telephone 1-800-521-8956
M. W. 775.02792 Fax
Purity ≥98% (HPLC) Email
Storage desiccated Chembase ID: 132608

SYNONYMS

Title
4-羟基他莫西芬
IUPAC name
4-[(1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol; 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
IUPAC Traditional name
4-[(1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol; 4-hydroxytamoxifen
Synonyms
(Z)-4-(1-[4-(二甲氨基乙氧基)苯基]-2-苯基-1-丁烯基)苯酚
4-OHT
(Z)-4-羟基三苯氧胺

DATABASE IDS

CAS Number 68392-35-8
PubChem SID 24895736

PROPERTIES

Purity ≥98% (HPLC)
Quality Level PREMIUM
Gene Information human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569)rat ... Ar(24208), Esr1(24890), Esr2(25149)
Apperance powder
Solubility methanol: soluble10 mg/mL
Solubility ethanol: soluble20 mg/mL (with heating)
GHS Pictograms GHS07
GHS Pictograms GHS08
GHS Signal Word Warning
GHS Hazard statements H302-H312-H332-H361
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P280
Risk Statements 63-20/21/22
RTECS SL1210000
Safety Statements 22-23-36
Storage Condition desiccated
Storage Condition protect from light
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (简体中文)
Biochem/physiol Actions
化疗药物他莫西芬的代谢物,表现出比原药更强效的雌激素激动剂/拮抗剂活性。还是脂质过氧化的活性膜内抑制剂。

REFERENCES