6-Maleimidohexanoic acid N-hydroxysuccinimide ester

• Catalog No.: M9794
• CAS Number: 55750-63-5
• M. F.: C14H16N2O6
• M. W.: 308.28664
• Purity: ≥98%

SYNONYMS

• Title: 6-(马来酰亚胺基)己酸琥珀酰亚胺酯
• IUPAC name: 2,5-dioxopyrrolidin-1-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
• IUPAC Traditional name: 2,5-dioxopyrrolidin-1-yl 6-(2,5-dioxopyrrol-1-yl)hexanoate
• Synonyms: EMCS; N-(ε-马来酰亚胺己酰氧)琥珀酰亚胺; 6-马来酰亚氨基己酸 N-琥珀酰亚胺酯; N-琥珀酰亚胺 6-马来酰亚胺己酸酯

DATABASE IDS

• MDL Number: MFCD00043043
• CAS Number: 55750-63-5
• Beilstein Number: 1499815

PROPERTIES

• Purity: ≥98%
• Apperance: powder
• Melting Point: 70-73 °C(lit.)
• Solubility: chloroform: soluble100 mg/mL
• Solubility: DMF: soluble (lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335-H351
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261-P281-P305 + P351 + P338
• Risk Statements: 36/37/38-40
• Safety Statements: 26-36/37
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Application
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.