β-Estradiol

• Catalog No.: E2758
• CAS Number: 50-28-2
• M. F.: C18H24O2
• M. W.: 272.38196
• Purity: ≥98%

SYNONYMS

• Title: β-雌二醇
• IUPAC name: (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,14-diol
• IUPAC Traditional name: estradiol
• Synonyms: 17β-雌二醇; 3,17β-二羟基-1,3,5(10)-雌甾三烯; 雌二醇; 1,3,5-雌甾三烯-3,17β-二醇

DATABASE IDS

• MDL Number: MFCD00003693
• Beilstein Number: 1914275
• CAS Number: 50-28-2
• PubChem SID: 24894483
• EC Number: 200-023-8

PROPERTIES

• Potency: 0.2-10 ng/mL
• Purity: ≥98%
• Suitability: suitable for cell culture
• Gene Information: human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)mouse ... Esr1(13982), Esr2(13983), Esrra(26379)rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
• Apperance: powder
• Melting Point: 176-180 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H351-H360Fd-H362
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P263-P281-P308 + P313
• Risk Statements: 60-63-40-64
• RTECS: KG2975000
• Safety Statements: 53-45
• German water hazard class: 3

DETAILS

Description (简体中文)

Application
β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).
Reconstitution
To prepare a 20 μg/ml stock solution, add 1 ml absolute ethanol to 1 mg β-estradiol; gently swirl to dissolve; add 49 ml sterile medium while mixing.
Physical form
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。