Netropsin dihydrochloride

• Catalog No.: N9653
• CAS Number: 1438-30-8
• M. F.: C18H28Cl2N10O3
• M. W.: 503.38612
• Purity: ≥98% (HPLC and TLC)

SYNONYMS

• IUPAC name: 4-[4-(2-carbamimidamidoacetamido)-1-methyl-1H-pyrrole-2-amido]-N-(2-carbamimidoylethyl)-1-methyl-1H-pyrrole-3-carboxamide dihydrochloride
• IUPAC Traditional name: 4-[4-(2-carbamimidamidoacetamido)-1-methylpyrrole-2-amido]-N-(2-carbamimidoylethyl)-1-methylpyrrole-3-carboxamide dihydrochloride
• Synonyms: Sinanomycin; Congocidin

DATABASE IDS

• CAS Number: 1438-30-8
• PubChem SID: 24897909
• MDL Number: MFCD00144883

PROPERTIES

• Biological Source: from Streptomyces netropsis
• Purity: ≥98% (HPLC and TLC)
• Apperance: faint yellow powder
• Solubility: H2O: soluble1 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22
• RTECS: DW2973000
• Safety Statements: 36
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Caution
Protect from light.
Biochem/physiol Actions
Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.