L-701,324

• Catalog No.: L0258
• CAS Number: 142326-59-8
• M. F.: C21H14ClNO3
• M. W.: 363.79376
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1,2-dihydroquinolin-2-one
• IUPAC Traditional name: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one
• Synonyms: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenylquinolin-2[1H]-one

DATABASE IDS

• MDL Number: MFCD00910917
• PubChem SID: 24278508
• CAS Number: 142326-59-8

PROPERTIES

• Purity: ≥98% (HPLC)
• Gene Information: human ... GRIN1(2902)rat ... Grin1(24408), Grin2a(24409)
• Apperance: solid
• Solubility: DMSO: soluble36.4 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (English)

Legal Information
Manufactured and sold under license from Merck, Sharp and Dohme, Ltd. U.S. Patent No. 5,348,962.
Biochem/physiol Actions
L-701,324 is a high affinity, selective antagonist at the glycine site of the NMDA glutamate receptor. L-701,324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents.