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Doxycycline hyclate_Molecular_structure_CAS_24390-14-5)
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Doxycycline hyclate

Catalog No. D9891 Name Sigma Aldrich
CAS Number 24390-14-5 Website http://www.sigmaaldrich.com
M. F. C46H58Cl2N4O18 Telephone 1-800-521-8956
M. W. 1025.87472 Fax
Purity ≥98% (TLC) Email
Storage Chembase ID: 132498

SYNONYMS

Title
多西环素 单盐酸半乙醇半水合物
IUPAC name
bis((4S,5S,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide) ethanol hydrate dihydrochloride
IUPAC Traditional name
bis((4S,5S,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide) ethyl alcohol hydrate dihydrochloride
Synonyms
多西环素盐酸盐半乙醇化物半水合物

DATABASE IDS

PubChem SID 24278399
MDL Number MFCD07357237
CAS Number 24390-14-5
Beilstein Number 5702728

PROPERTIES

Purity ≥98% (TLC)
Solubility Do you have solubility information on this product that you would like to share?
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H315-H319-H335
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 22-36/37/38
RTECS QI8925000
Safety Statements 26
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Frequently Asked Questions
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Application
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Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks1. It is used to inhibit matrix metalloproteinases2 and has been used to inhibit the inflammatory response of Lyme Disease3.
Biochem/physiol Actions
Derivative of oxytetracycline. A broad spectrum inhibitor used to inhibit matrix metallo-proteinases (MMP) such as type 1 collagenase in studies on would healing and tissue remodeling.
Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi3. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

REFERENCES