Capreomycin sulfate from Streptomyces capreolus

• Catalog No.: C4142
• CAS Number: 1405-37-4
• M. F.: C24H44N14O12S
• M. W.: 752.75776

SYNONYMS

• IUPAC name: (2S)-2,5-diamino-N-{[(2S,5R,8Z,11S,15R)-15-amino-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-11-(2-imino-1,3-diazinan-4-yl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}pentanamide; sulfuric acid
• IUPAC Traditional name: (2S)-2,5-diamino-N-{[(2S,5R,8Z,11S,15R)-15-amino-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-11-(2-imino-1,3-diazinan-4-yl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}pentanamide; sulfuric acid

DATABASE IDS

• CAS Number: 1405-37-4
• MDL Number: MFCD00079032
• PubChem SID: 24892668
• EC Number: 215-776-8

PROPERTIES

• GHS Signal Word: Danger
• GHS Hazard statements: H302-H312-H332-H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P280-P308 + P313
• Risk Statements: 61-20/21/22
• RTECS: EX8930000
• Safety Statements: 53-22-36/37/39-45
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis 1,2.
Capreomycin sulfate is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis.
Biochem/physiol Actions
Capreomycin sulfate binds across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix 44 (h44) 3.