Brefeldin A

• Catalog No.: B7651
• CAS Number: 20350-15-6
• M. F.: C16H24O4
• M. W.: 280.35936
• Purity: ≥99% (HPLC and TLC)

SYNONYMS

• IUPAC name: (1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
• IUPAC Traditional name: brefeldin A
• Synonyms: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone; Cyanein; BFA; Decumbin; Ascotoxin

DATABASE IDS

• MDL Number: MFCD12913297
• PubChem SID: 24278285
• Beilstein Number: 25191
• CAS Number: 20350-15-6

PROPERTIES

• Biological Source: from Penicillium brefeldianum
• Purity: ≥99% (HPLC and TLC)
• Quality Level: PREMIUM
• Solubility: ethanol: soluble1-5 mg/mL (Store stock solutions at -20 °C.)
• Solubility: methanol: soluble10 mg/mL (Store stock solutions at -20 °C.)
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22
• RTECS: GY8410000
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.