Radicicol from Diheterospora chlamydosporia

• Catalog No.: R2146
• CAS Number: 12772-57-5
• M. F.: C18H17ClO6
• M. W.: 364.77698

SYNONYMS

• IUPAC name: (4R,6R,8R,9Z,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.0^6,^8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
• IUPAC Traditional name: (4R,6R,8R,9Z,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.0^6,^8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
• Synonyms: Monorden; [1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

DATABASE IDS

• PubChem SID: 24899351
• CAS Number: 12772-57-5
• MDL Number: MFCD06795865

PROPERTIES

• Gene Information: human ... HSP90AA1(3320), SRC(6714)rat ... Src(83805)
• Apperance: yellow solid
• Solubility: ethanol: soluble10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H335-H340-H350
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P201-P261-P301 + P310-P305 + P351 + P338-P308 + P313
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 45-46-22-36/37/38
• Safety Statements: 53-26-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.
Caution
Photosensitive