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Anisomycin from Streptomyces griseolus_Molecular_structure_CAS_22862-76-6)
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Anisomycin from Streptomyces griseolus

Catalog No. A9789 Name Sigma Aldrich
CAS Number 22862-76-6 Website http://www.sigmaaldrich.com
M. F. C14H19NO4 Telephone 1-800-521-8956
M. W. 265.30496 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 5025


IUPAC name
(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl acetate
IUPAC Traditional name
2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate


EC Number 245-269-7
MDL Number MFCD00077650
Beilstein Number 20705
CAS Number 22862-76-6
PubChem SID 24891496


Purity ≥98% (HPLC)
Quality Level PREMIUM
Apperance white to faint yellow solid
Solubility H2O: soluble2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.)
Solubility DMSO: soluble20 mg/mL
Solubility methanol: soluble20 mg/mL
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Precautionary statements P301 + P310
RID/ADR UN 3462 6.1/PG 3
Risk Statements 25
RTECS BZ9800000
Safety Statements 45
Storage Temperature 2-8°C
Hazard Class 6.1
UN Number 3462
Packing Group 3
German water hazard class 3


Description (English)
Biochem/physiol Actions
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.