Trimethoprim

• Catalog No.: T7883
• CAS Number: 738-70-5
• M. F.: C14H18N4O3
• M. W.: 290.31772
• Purity: ≥98% (TLC)

SYNONYMS

• Title: 甲氧苄啶
• IUPAC name: 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
• IUPAC Traditional name: trimethoprim
• Synonyms: 2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶

DATABASE IDS

• MDL Number: MFCD00036761
• Beilstein Number: 625127
• PubChem SID: 24278201
• EC Number: 212-006-2
• CAS Number: 738-70-5

PROPERTIES

• Purity: ≥98% (TLC)
• Gene Information: human ... DHFRP1(573971), KCNH1(3756)rat ... Dhfr(24312)
• Apperance: white powder
• Solubility: DMSO: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: UV8225000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections1.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase2,3.
Biochem/physiol Actions
The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis1.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information