Nystatin

• Catalog No.: N3503
• CAS Number: 1400-61-9
• M. F.: C47H75NO17
• M. W.: 926.0949

SYNONYMS

• IUPAC name: (1S,3R,4R,7R,9R,11R,15S,16S,17R,18S,19Z,21Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
• IUPAC Traditional name: (1S,3R,4R,7R,9R,11R,15S,16S,17R,18S,19Z,21Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
• Synonyms: Mycostatin; Fungicidin

DATABASE IDS

• EC Number: 215-749-0
• CAS Number: 1400-61-9
• PubChem SID: 24897647

PROPERTIES

• Quality Level: PREMIUM
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: RF5950000
• Storage Temperature: -20°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Mode of Action: Increases the permeability of the cell membrane of sensitive fungi by binding to sterols.Antimicrobial spectrum: Yeasts and molds.
Nystatin binds to ergosterol in fungal cell membranes which causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death. Antimicrobial spectrum: Yeasts and molds.
Application
Product N3503 is ≥4,400 USP units/mg. Nystatin is a polyene, antifungal antibiotic with potent proinflammatory properties. It has many applications such as preventing cell culture contamination and inducing interleukin (IL)-, IL-8, and tumor necrosis factor α s secretion in TLR2-expressing THP1 cells 1. It is used as a fungal membrane (ergosterol binding) pore forming agent and to create nystatin/ergosterol based ion channels in lipid bilayers.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information