Tetracycline

• Catalog No.: T3258
• CAS Number: 60-54-8
• M. F.: C22H24N2O8
• M. W.: 444.43456
• Purity: ≥88.0% (HPLC)

SYNONYMS

• Title: 四环素
• IUPAC name: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• IUPAC Traditional name: tetracycline

DATABASE IDS

• MDL Number: MFCD00151232
• EC Number: 200-481-9
• PubChem SID: 24900120
• CAS Number: 60-54-8
• Beilstein Number: 2230417

PROPERTIES

• Purity: ≥88.0% (HPLC)
• Gene Information: human ... CYP1A2(1544), TERT(7015)
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• RTECS: QI8750000
• Safety Statements: 22-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Tetracycline is a broad spectrum polyketide antibiotic. It is used clinically to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, and Brill-Zinsser disease. It is used to treat upper respiratory infections and acne1. It is used to study multidrug resistance2 as well as potential side effects such as acute pancreatitis3.
Biochem/physiol Actions
Tetracycline inhibits bacterial protein synthesis elongation at the level of aminoacyl-tRNA binding to the 30S ribosome. Tetracycline passively diffuses through porin channels in the bacterial cell membrane. It also binds to the bacterial 50S ribosomal subunit which may alter the cytoplasmic membrane, causing intracellular components to leak from bacterial cells1. Mode of resistance is via loss of cell wall permeability.