Vinblastine sulfate salt

• Catalog No.: V1377
• CAS Number: 143-67-9
• M. F.: C46H60N4O13S
• M. W.: 909.0526
• Purity: ≥96% (HPLC)

SYNONYMS

• IUPAC name: sulfuric acid methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• IUPAC Traditional name: sulfuric acid; vinblastine
• Synonyms: Vincaleukoblastine sulfate salt; VLB

DATABASE IDS

• Beilstein Number: 3659812
• MDL Number: MFCD00082457
• EC Number: 205-606-0
• PubChem SID: 24278771
• CAS Number: 143-67-9

PROPERTIES

• Purity: ≥96% (HPLC)
• Gene Information: human ... TBCC(6903)
• Absorption Wavelength: A1mM/214 nm, ethanol 53.7
• Absorption Wavelength: A1mM/259 nm, ethanol 16.2
• Absorption Wavelength: A1mM/270 nm, 0.1 M phosphate buffer 14
• Apperance: white powder
• Melting Point: 267 °C (dec.)(lit.)
• Solubility: H2O: soluble10 mg/mL
• Solubility: DMSO: soluble50 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H315-H318-H335
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 22-37/38-41
• Safety Statements: 26-36/39
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.