N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

• Catalog No.: D0627
• CAS Number: 16980-89-5
• M. F.: C18H23N5NaO8P
• M. W.: 491.367451
• Purity: ≥96% (HPLC)

SYNONYMS

• Title: N6,2′-O-二丁酰基腺苷3′,5′-环磷酸 钠盐
• IUPAC name: sodium (4aR,6R,7R,7aR)-6-(6-butanamido-9H-purin-9-yl)-7-(butanoyloxy)-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• IUPAC Traditional name: sodium (4aR,6R,7R,7aR)-6-(6-butanamidopurin-9-yl)-7-(butanoyloxy)-2-oxo-tetrahydro-4H-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• Synonyms: 布拉地新 钠盐; 二丁酰环磷腺苷 钠盐; 二丁酰 cAMP 钠盐

DATABASE IDS

• CAS Number: 16980-89-5
• PubChem SID: 24893246
• MDL Number: MFCD00005843
• EC Number: 241-059-4

PROPERTIES

• Impurities: ≤0.5% Cyclic AMP
• Impurities: ≤3% monobutyryl derivatives
• Purity: ≥96% (HPLC)
• Apperance: off-white powder
• Solubility: H2O: soluble50 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: ES5055500
• Storage Temperature: -20°C
• German water hazard class: 2

DETAILS

Description (简体中文)

Biochem/physiol Actions
细胞通透性 cAMP 类似物，可激活 cAMP 依赖性蛋白激酶 (PKA)。
Caution
在 pH 8.5 下会失去 2′-O-丁酰基
Application
Dibutyryl cAMP is a cell-permeable cAMP analogue that activates cAMP dependent protein kinase (PKA) or the cAMP/PKA signaling pathway. Dibutyryl cAMP is used as a morphological differentiation inducer and cell signaling modulator in cells such as Schwann cells. It is used in a variety of neural differentiation studies.