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Bestatin hydrochloride_Molecular_structure_CAS_65391-42-6)
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Bestatin hydrochloride

Catalog No. B8385 Name Sigma Aldrich
CAS Number 65391-42-6 Website http://www.sigmaaldrich.com
M. F. C16H25ClN2O4 Telephone 1-800-521-8956
M. W. 344.8337 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 132429


IUPAC name
(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid hydrochloride
IUPAC Traditional name
ubenimex hydrochloride
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride


MDL Number MFCD00058004
PubChem SID 24278278
Beilstein Number 4628066
CAS Number 65391-42-6


Purity ≥98% (HPLC)
Quality Level PREMIUM
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature -20°C
German water hazard class 3


Description (English)
Preparation Note
Solubility testing in water at 25 mg/ml yields a clear solution. Stock solutions at 1 mM are expected to be stable at least one month stored at -20 °C.
Biochem/physiol Actions
A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.1