N-tert-Butyl-α-phenylnitrone

• Catalog No.: B7263
• CAS Number: 3376-24-7
• M. F.: C11H15NO
• M. W.: 177.2429
• Purity: ≥98% (GC)

SYNONYMS

• Title: N-叔丁基-α-苯基硝酮
• IUPAC name: (Z)-N-tert-butyl-1-phenylmethenimine oxide
• IUPAC Traditional name: (Z)-N-tert-butyl-1-phenylmethenimine oxide
• Synonyms: 苯基·N-叔丁基硝酮; N-苯亚甲基-叔丁胺-N-氧化物; PBN

DATABASE IDS

• CAS Number: 3376-24-7
• MDL Number: MFCD00008799
• EC Number: 222-168-6
• Beilstein Number: 2044028
• PubChem SID: 24891981

PROPERTIES

• Purity: ≥98% (GC)
• Apperance: white powder
• Melting Point: 73-74 °C(lit.)
• Solubility: DMSO: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: TX1760000
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

包装
1, 5 g in glass bottle
Biochem/physiol Actions
N-tert-butyl-α-phenylnitrone (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.1 The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100Å g).