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P1,P5-Di(adenosine-5′) pentaphosphate trilithium salt_Molecular_structure_CAS_75522-97-3)
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P1,P5-Di(adenosine-5′) pentaphosphate trilithium salt

Catalog No. D6392 Name Sigma Aldrich
CAS Number 75522-97-3 Website http://www.sigmaaldrich.com
M. F. C20H24Li5N10O22P5 Telephone 1-800-521-8956
M. W. 946.032165 Fax
Purity ≥95% Email
Storage Chembase ID: 132413


IUPAC name
pentalithium(1+) ion ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]oxy}phosphinato)oxy]phosphinate
IUPAC Traditional name
pentalithium(1+) ion Ap5A
A(5′)P5(5′)A trilithium salt
Diadenosine pentaphosphate trilithium salt


PubChem SID 24894024
CAS Number 75522-97-3
EC Number 278-237-6
MDL Number MFCD00044936


Purity ≥95%
Apperance white to white with yellow cast powder
Solubility H2O: soluble50 mg/mL
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature -20°C
German water hazard class 3


Description (English)
Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.1