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Cytochalasin D

Catalog No. C8273 Name Sigma Aldrich
CAS Number 22144-77-0 Website http://www.sigmaaldrich.com
M. F. C30H37NO6 Telephone 1-800-521-8956
M. W. 507.61788 Fax
Purity ≥98% (TLC and HPLC) Email
Storage Chembase ID: 132393

SYNONYMS

Title
细胞松弛素 D
IUPAC name
(3S,4S,6S,6aR,10S,12R,15R,15aR,15bR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-1H,2H,3H,4H,5H,6H,6aH,9H,10H,11H,12H,15H,15bH-cycloundeca[e]isoindol-15-yl acetate
IUPAC Traditional name
cytochalasin D
Synonyms
松胞菌素 D

DATABASE IDS

EC Number 244-804-1
MDL Number MFCD00077706
Beilstein Number 1632828
PubChem SID 24893039
CAS Number 22144-77-0

PROPERTIES

Biological Source from Zygosporium mansonii
Purity ≥98% (TLC and HPLC)
Quality Level PREMIUM
Apperance powder
Solubility DMSO: soluble
Solubility ethanol: soluble
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H300-H361
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P264-P281-P301 + P310
RID/ADR UN 1544 6.1/PG 2
Risk Statements 63-25
RTECS GZ4850000
Safety Statements 36/37-45
Storage Temperature -20°C
Hazard Class 6.1
UN Number 1544
Packing Group 2
German water hazard class 3

DETAILS

Description (简体中文)
Biochem/physiol Actions
肌动蛋白聚合化的强效抑制剂;破坏肌动蛋白微丝;活化 p53 依赖性途径;抑制平滑肌收缩;抑制胰岛素刺激的糖转运。
Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.

REFERENCES