Tyrphostin A9

• Catalog No.: T182
• CAS Number: 10537-47-0
• M. F.: C18H22N2O
• M. W.: 282.38008

SYNONYMS

• IUPAC name: 2-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
• IUPAC Traditional name: 2-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
• Synonyms: Malonoben; [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile

DATABASE IDS

• MDL Number: MFCD00209853
• CAS Number: 10537-47-0
• PubChem SID: 24278069

PROPERTIES

• Gene Information: human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159)mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)
• Apperance: yellow solid
• Solubility: ethanol: soluble20 mg/mL
• Solubility: DMSO: <25 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H311-H331
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P280-P301 + P310-P311
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 23/24/25
• RTECS: OO3737000
• Safety Statements: 36/37/39-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Inhibitor of calcium release-activated calcium (CRAC) channels (see Dennis et al.)
Selective inhibitor of PDGF receptor tyrosine kinase.