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cis-4-Hydroxy-L-proline_Molecular_structure_CAS_618-27-9)
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cis-4-Hydroxy-L-proline

Catalog No. H1637 Name Sigma Aldrich
CAS Number 618-27-9 Website http://www.sigmaaldrich.com
M. F. C5H9NO3 Telephone 1-800-521-8956
M. W. 131.12986 Fax
Purity Email
Storage Chembase ID: 132377

SYNONYMS

Title
顺式-4-羟基-L-脯氨酸
IUPAC name
(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
IUPAC Traditional name
L-hydroxyproline
Synonyms
(2S,4S)-(-)-4-羟基-2-吡咯烷羧酸
CHP

DATABASE IDS

EC Number 210-542-1
CAS Number 618-27-9
Beilstein Number 81440
MDL Number MFCD00064319
PubChem SID 24895470

PROPERTIES

Melting Point 257 °C (dec.)(lit.)
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
German water hazard class 3

DETAILS

Description (English)
Other Notes
Constituent of Amanita sp. peptide toxins but not of animal proteins like collagen.
Application
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound.1 CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells.2 CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A.4

REFERENCES