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Aminopterin

Catalog No. A5159 Name Sigma Aldrich
CAS Number 54-62-6 Website http://www.sigmaaldrich.com
M. F. C19H20N8O5 Telephone 1-800-521-8956
M. W. 440.4127 Fax
Purity Email
Storage Chembase ID: 132374

SYNONYMS

Title
氨基蝶呤
IUPAC name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
IUPAC Traditional name
4-aminopteroylglutamic acid
Synonyms
4-氨基叶酸
4-氨基-PGA
N-[4-[[(2,4-二氨基-6-蝶啶)甲基]氨基]苯甲酰]-L-谷氨酸

DATABASE IDS

CAS Number 54-62-6
Beilstein Number 69045
EC Number 200-209-9
PubChem SID 24890950
MDL Number MFCD00036692

PROPERTIES

Concentration 50 ×
Grade Hybri-Max™
Impurities endotoxin, tested
Shipped in dry ice
Sterility γ-irradiated
Suitability suitable for hybridoma
Gene Information human ... FPGS(2356)mouse ... Fpgs(14287)
Absorption Wavelength ε1M/261 nm, 0.1 M NaOH 25,700
Absorption Wavelength ε1M/282 nm, 0.1 M NaOH 24,500
Absorption Wavelength ε1M/373 nm, 0.1 M NaOH 8,100
Apperance lyophilized powder
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H300-H360
European Hazard Symbols Highly toxic Highly toxic (T+)
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P264-P301 + P310-P308 + P313
RID/ADR UN 2811 6.1/PG 1
Risk Statements 61-28
RTECS MA1050000
Safety Statements 53-28-36/37-45
Storage Temperature -20°C
Hazard Class 6.1
UN Number 2811
Packing Group 1
German water hazard class 3

DETAILS

Description (简体中文)
Application
用于杂交瘤细胞培养应用的氨基蝶呤浓缩物添加剂。
Linkage
比甲氨喋呤更有效,但毒性也更强。
Reconstitution
10mL 无菌细胞培养基可复原一小瓶本品。储备液足以制备 500mL 培养基。最终工作浓度:0.4μM 氨基蝶呤。
Biochem/physiol Actions
叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内,它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物,该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。
法律信息
Hybri-Max 商标 Sigma-Aldrich Co. LLC
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A5159.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

REFERENCES