3-Methyladenine

• Catalog No.: M9281
• CAS Number: 5142-23-4
• M. F.: C7H8N4
• M. W.: 148.16522

SYNONYMS

• IUPAC name: 1-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-amine
• IUPAC Traditional name: 1-methylpyrrolo[2,3-d]pyrimidin-4-amine
• Synonyms: 6-Amino-3-methylpurine; 3-MA

DATABASE IDS

• PubChem SID: 24897326
• EC Number: 225-908-6
• Beilstein Number: 146087
• CAS Number: 5142-23-4
• MDL Number: MFCD00010531

PROPERTIES

• Quality Level: PREMIUM
• Melting Point: ~300 °C (dec.)(lit.)
• RTECS: AU6520000
• German water hazard class: 3

DETAILS

Description (English)

Preparation Note
This product is soluble in DMF (10 mg/ml, may require gentle heating), yielding a clear, colorless solution. It is also soluble in water, 95% ethanol, or 1 N NaOH at 30 mg/ml with heating, but upon cooling, the product precipitates from solution. Solutions of 3-MA are best prepared fresh.
Application
3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.