6-Aminocaproic acid

• Catalog No.: A2504
• CAS Number: 60-32-2
• M. F.: C6H13NO2
• M. W.: 131.17292
• Purity: ≥99% (titration)

SYNONYMS

• Title: 6-氨基己酸
• IUPAC name: 6-aminohexanoic acid
• IUPAC Traditional name: aminocaproic acid
• Synonyms: EACA; 6-氨己酸; ε-氨基己酸

DATABASE IDS

• EC Number: 200-469-3
• MDL Number: MFCD00008238
• Beilstein Number: 906872
• CAS Number: 60-32-2
• PubChem SID: 24890662

PROPERTIES

• Purity: ≥99% (titration)
• Gene Information: human ... PLG(5340)rat ... Ppm1a(24666)
• Apperance: white powder
• Melting Point: 207-209 °C (dec.)(lit.)
• Solubility: H2O: soluble50 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: MO6300000
• Safety Statements: 26-36
• German water hazard class: 2

DETAILS

Description (简体中文)

包装
1 kg in poly bottle
25, 100, 500 g in poly bottle
5 kg in poly drum
Application
EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
Biochem/physiol Actions
EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo-xy-peptidase, plasmin, and plasminogen activator.
赖氨酸类似物。促进纤溶酶快速解离，从而抑制纤溶酶原的活化以及后续的纤维蛋白溶解。据报告，EACA 可抑制纤溶酶原结合至活化的血小板。早期报告表明，EACA 可抑制补体系统第一组分的活化。结合并灭活羧肽酶 B。