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6-Aminocaproic acid

Catalog No. A2504 Name Sigma Aldrich
CAS Number 60-32-2 Website http://www.sigmaaldrich.com
M. F. C6H13NO2 Telephone 1-800-521-8956
M. W. 131.17292 Fax
Purity ≥99% (titration) Email
Storage Chembase ID: 395

SYNONYMS

Title
6-氨基己酸
IUPAC name
6-aminohexanoic acid
IUPAC Traditional name
aminocaproic acid
Synonyms
EACA
6-氨己酸
ε-氨基己酸

DATABASE IDS

EC Number 200-469-3
MDL Number MFCD00008238
Beilstein Number 906872
CAS Number 60-32-2
PubChem SID 24890662

PROPERTIES

Purity ≥99% (titration)
Gene Information human ... PLG(5340)rat ... Ppm1a(24666)
Apperance white powder
Melting Point 207-209 °C (dec.)(lit.)
Solubility H2O: soluble50 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
RTECS MO6300000
Safety Statements 26-36
German water hazard class 2

DETAILS

Description (简体中文)
包装
1 kg in poly bottle
25, 100, 500 g in poly bottle
5 kg in poly drum
Application
EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
Biochem/physiol Actions
EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo-xy-peptidase, plasmin, and plasminogen activator.
赖氨酸类似物。促进纤溶酶快速解离,从而抑制纤溶酶原的活化以及后续的纤维蛋白溶解。据报告,EACA 可抑制纤溶酶原结合至活化的血小板。早期报告表明,EACA 可抑制补体系统第一组分的活化。结合并灭活羧肽酶 B。

REFERENCES