Aflatoxin B1 from Aspergillus flavus

• Catalog No.: A6636
• CAS Number: 1162-65-8
• M. F.: C17H12O6
• M. W.: 312.27358
• Purity: ≥98% (TLC and HPLC)

SYNONYMS

• Title: 黄曲霉素 B1 来源于黄曲霉
• IUPAC name: (3S,7R)-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0^2,^9.0^3,^7.0^1^3,^1^7]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione
• IUPAC Traditional name: aflatoxin B1

DATABASE IDS

• CAS Number: 1162-65-8
• Beilstein Number: 1269174
• EC Number: 214-603-3
• MDL Number: MFCD00869647
• PubChem SID: 24891116

PROPERTIES

• Biological Source: from Aspergillus flavus
• Purity: ≥98% (TLC and HPLC)
• Quality Level: PREMIUM
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330-H350
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P260-P264-P280-P284-P301 + P310
• RID/ADR: UN 3462 6.1/PG 1
• Risk Statements: 45-46-26/27/28
• RTECS: GY1925000
• Safety Statements: 53-28-36/37-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (简体中文)

Warning
可能致癌。
Application
Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products.
Biochem/physiol Actions
Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR).
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A6636.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.