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Methoctramine hydrate_Molecular_structure_CAS_104807-46-7(anhydrous))
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Methoctramine hydrate

Catalog No. M105 Name Sigma Aldrich
CAS Number 104807-46-7(anhydrous) Website http://www.sigmaaldrich.com
M. F. C72H130Cl4N8O5 Telephone 1-800-521-8956
M. W. 1329.6652 Fax
Purity ≥97% (NMR) Email
Storage Chembase ID: 132369

SYNONYMS

IUPAC name
bis(1,26-bis(2-methoxyphenyl)-2,9,18,25-tetraazahexacosane) hydrate tetrahydrochloride
IUPAC Traditional name
bis(1,26-bis(2-methoxyphenyl)-2,9,18,25-tetraazahexacosane) hydrate tetrahydrochloride
Synonyms
N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate
Methoctramine tetrahydrochloride hydrate

DATABASE IDS

MDL Number MFCD11045942
CAS Number 104807-46-7(anhydrous)
PubChem SID 24277850

PROPERTIES

Purity ≥97% (NMR)
Gene Information human ... CHRM2(1129)
Apperance white solid
Solubility H2O: >20 mg/mL
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. The increase in calcium and arachidonic acid release were attenuated by the M2 receptor antagonist methoctramine, but not by the M3 receptor antagonist p-fluoro-hexahydro siladifenidol.

REFERENCES