Methoctramine hydrate

• Catalog No.: M105
• CAS Number: 104807-46-7(anhydrous)
• M. F.: C72H130Cl4N8O5
• M. W.: 1329.6652
• Purity: ≥97% (NMR)

SYNONYMS

• IUPAC name: bis(1,26-bis(2-methoxyphenyl)-2,9,18,25-tetraazahexacosane) hydrate tetrahydrochloride
• IUPAC Traditional name: bis(1,26-bis(2-methoxyphenyl)-2,9,18,25-tetraazahexacosane) hydrate tetrahydrochloride
• Synonyms: N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate; Methoctramine tetrahydrochloride hydrate

DATABASE IDS

• MDL Number: MFCD11045942
• CAS Number: 104807-46-7(anhydrous)
• PubChem SID: 24277850

PROPERTIES

• Purity: ≥97% (NMR)
• Gene Information: human ... CHRM2(1129)
• Apperance: white solid
• Solubility: H2O: >20 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. The increase in calcium and arachidonic acid release were attenuated by the M2 receptor antagonist methoctramine, but not by the M3 receptor antagonist p-fluoro-hexahydro siladifenidol.