S-(5′-Adenosyl)-L-methionine iodide

• Catalog No.: A4377
• CAS Number: 3493-13-8
• M. F.: C15H23IN6O5S
• M. W.: 526.34979
• Purity: ≥80% (HPLC)

SYNONYMS

• IUPAC name: [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium iodide
• IUPAC Traditional name: SAMe iodide
• Synonyms: AdoMet; SAM

DATABASE IDS

• MDL Number: MFCD00043192
• PubChem SID: 24890852
• Beilstein Number: 4120787
• EC Number: 222-486-5
• CAS Number: 3493-13-8

PROPERTIES

• Biological Source: from yeast
• Purity: ≥80% (HPLC)
• Purity: ≥80% (spectrophotometric assay)
• Shipped in: dry ice
• Solubility: H2O: soluble100 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H317
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS Precautionary statements: P280
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Analysis Note
Purity based on UV and HPLC.
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Caution
This material is very unstable at room temperature.