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Patulin

Catalog No. P1639 Name Sigma Aldrich
CAS Number 149-29-1 Website http://www.sigmaaldrich.com
M. F. C7H6O4 Telephone 1-800-521-8956
M. W. 154.12014 Fax
Purity ≥98% (TLC) Email
Storage Chembase ID: 105386

SYNONYMS

Title
棒曲霉素
IUPAC name
4-hydroxy-2H,4H,6H-furo[3,2-c]pyran-2-one
IUPAC Traditional name
patulin
Synonyms
4-羟基-4H-呋[3,2-c]吡喃-2(6H)-酮

DATABASE IDS

MDL Number MFCD00005858
PubChem SID 24898227
Beilstein Number 149675
EC Number 205-735-2
CAS Number 149-29-1

PROPERTIES

Purity ≥98% (TLC)
Quality Level PREMIUM
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H300-H315
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, Gloves
GHS Precautionary statements P264-P301 + P310
RID/ADR UN 3462 6.1/PG 2
Risk Statements 25-38
RTECS LV2625000
Safety Statements 45
Storage Temperature -20°C
Hazard Class 6.1
UN Number 3462
Packing Group 2
German water hazard class 3

DETAILS

Description (English)
Application
Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It is commonly found in apples. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking. It is used to study patulin contamination of bottled wine 1, DNA-damaging activity of patulin in Escherichia coli.2, and molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in patulin biosynthesis3.
Biochem/physiol Actions
Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking. CYP619 cytochrome P450s are involved in biosynthesis of patulin in Aspergillus clavatus3.

REFERENCES