Sulfamethazine

• Catalog No.: S6256
• CAS Number: 57-68-1
• M. F.: C12H14N4O2S
• M. W.: 278.33016
• Purity: ≥99%

SYNONYMS

• Title: 磺胺二甲基嘧啶
• IUPAC name: 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide
• IUPAC Traditional name: sulfamethazine
• Synonyms: 4,6-二甲基磺胺嘧啶; 磺胺二甲嘧啶; 4-氨基-N-(4,6-二甲基-2-嘧啶基)苯磺酰胺

DATABASE IDS

• Beilstein Number: 261304
• MDL Number: MFCD00006066
• EC Number: 200-346-4
• PubChem SID: 24899686
• CAS Number: 57-68-1

PROPERTIES

• Purity: ≥99%
• Suitability: suitable for 1694 per US EPA
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: WO9275000
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.
Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
Application
Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections1. It is used in disposition and depletion kinetic studies2,3. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine4.