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α-Lobeline hydrochloride_Molecular_structure_CAS_134-63-4)
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α-Lobeline hydrochloride

Catalog No. L4376 Name Sigma Aldrich
CAS Number 134-63-4 Website http://www.sigmaaldrich.com
M. F. C22H28ClNO2 Telephone 1-800-521-8956
M. W. 373.91622 Fax
Purity Email
Storage Chembase ID: 110145

SYNONYMS

Title
α-洛贝林 盐酸盐
IUPAC name
2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethan-1-one hydrochloride
IUPAC Traditional name
(-)-lobeline hydrochloride
Synonyms
2-[6-(2-羟基-2-苯乙基)-1-甲基-2-呱啶基]-1-苯乙酮 盐酸盐
(-)-洛贝林 盐酸盐

DATABASE IDS

EC Number 205-150-2
CAS Number 134-63-4
Beilstein Number 3920196
MDL Number MFCD00082455

PROPERTIES

Gene Information human ... SLC18A2(6571)
Apperance white to off-white powder
Solubility H2O: soluble25 mg/mL
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301-H331
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Precautionary statements P261-P301 + P310-P311
RID/ADR UN 1544 6.1/PG 3
Risk Statements 23/25
RTECS OJ8490100
Safety Statements 36/37/39-45
Hazard Class 6.1
UN Number 1544
Packing Group 3
German water hazard class 3

DETAILS

Description (简体中文)
Biochem/physiol Actions
高亲和性神经元烟碱型乙酰胆碱受体激动剂;呼吸兴奋剂。通过与囊泡单胺转运体 (VMAT2) 的四苯喹嗪结合位点相互作用来抑制多巴胺的突触积累。阻断安非他明诱导的多巴胺释放。

REFERENCES