α-Lobeline hydrochloride

• Catalog No.: L4376
• CAS Number: 134-63-4
• M. F.: C22H28ClNO2
• M. W.: 373.91622

SYNONYMS

• Title: α-洛贝林 盐酸盐
• IUPAC name: 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethan-1-one hydrochloride
• IUPAC Traditional name: (-)-lobeline hydrochloride
• Synonyms: 2-[6-(2-羟基-2-苯乙基)-1-甲基-2-呱啶基]-1-苯乙酮 盐酸盐; (-)-洛贝林 盐酸盐

DATABASE IDS

• EC Number: 205-150-2
• CAS Number: 134-63-4
• Beilstein Number: 3920196
• MDL Number: MFCD00082455

PROPERTIES

• Gene Information: human ... SLC18A2(6571)
• Apperance: white to off-white powder
• Solubility: H2O: soluble25 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H331
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P301 + P310-P311
• RID/ADR: UN 1544 6.1/PG 3
• Risk Statements: 23/25
• RTECS: OJ8490100
• Safety Statements: 36/37/39-45
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
高亲和性神经元烟碱型乙酰胆碱受体激动剂；呼吸兴奋剂。通过与囊泡单胺转运体 (VMAT2) 的四苯喹嗪结合位点相互作用来抑制多巴胺的突触积累。阻断安非他明诱导的多巴胺释放。