Kazusamycin A

• Catalog No.: K1764
• CAS Number: 92090-94-3
• M. F.: C33H48O7
• M. W.: 556.73002
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (2E,10E,12E,16E,18E)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• IUPAC Traditional name: (2E,10E,12E,16E,18E)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid

DATABASE IDS

• MDL Number: MFCD03265635
• CAS Number: 92090-94-3

PROPERTIES

• Biological Source: from Streptomyces sp.
• Purity: ≥95% (HPLC)
• Shipped in: dry ice
• Apperance: aqueous methanol solution
• Flash Point: 15 °C
• Flash Point: 59 °F
• Solubility: methanol: water: soluble7:3
• Solubility: DMSO: soluble
• Solubility: H2O: insoluble
• Solubility: chloroform: soluble
• Solubility: ethanol: soluble
• Solubility: hexane: insoluble
• Solubility: methanol: soluble
• GHS Signal Word: Danger
• GHS Hazard statements: H225-H301-H311-H331-H370
• European Hazard Symbols: Flammable (F)
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P210-P260-P280-P301 + P310-P311
• RID/ADR: UN 1230 3/PG 2
• Risk Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• Storage Temperature: -20°C
• Hazard Class: 3
• UN Number: 1230
• Packing Group: 2
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
Kazusamycin A, an unsaturated branched chain fatty acid with a terminal lactone ring, is a hydroxy analog of Leptomycin B. It has significant in vitro cytotoxic activity against various human and mouse tumor lines encompassing a wide range of tissue types. Kazusamycin A exhibits in vivo antitumor activity against experimental murine tumors. It inhibits nuclear export and Rev translocation, a regulatory gene product in the HIV genome, at nanomolar concentrations.
Physical form
70% methanol solution.