1,2-Dioctanoyl-sn-glycerol

• Catalog No.: D5156
• CAS Number: 60514-48-9
• M. F.: C19H36O5
• M. W.: 344.48614
• Purity: ≥96% (TLC)

SYNONYMS

• IUPAC name: (2S)-1-hydroxy-3-(octanoyloxy)propan-2-yl octanoate
• IUPAC Traditional name: (2S)-1-hydroxy-3-(octanoyloxy)propan-2-yl octanoate
• Synonyms: 1,2-Dicapryloyl-sn-glycerol; D-α,β-Dicaprylin; (S)-Glycerol 1,2-dioctanoate; DOG

DATABASE IDS

• PubChem SID: 24893929
• CAS Number: 60514-48-9
• Beilstein Number: 1714754
• MDL Number: MFCD00036835

PROPERTIES

• Purity: ≥96% (TLC)
• Shipped in: dry ice
• Apperance: yellow oil
• Solubility: DMSO: soluble
• Personal Protective Equipment: Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• RTECS: RH0764500
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Caution
Some isomerization to the 1,3-isomer may occur in storage or in solution.
Other Notes
Synthetic 1,2-diglyceride of short chain fatty acid.
Biochem/physiol Actions
Cell-permeable, diacylglycerol (DAG) analog, and activator of protein kinase C (PKC). Shown to possess a lower affinity for the α isoform of PKC than for the other isoforms. Mimics the action of tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA). Inhibits slow (L-type) Ca2+ current in rat heart cells independently of PKC activation and also inhibits the cGMP-gated channel in rod outer segments by a phosphorylation-independent mechanism.