trans-Dehydroandrosterone

• Catalog No.: D4000
• CAS Number: 53-43-0
• M. F.: C19H28O2
• M. W.: 288.42442
• Purity: ≥99%

SYNONYMS

• Title: 反式-脱氢雄甾酮
• IUPAC name: (1S,2R,5S,10R,11S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-7-en-14-one
• IUPAC Traditional name: dehydroepiandrosterone
• Synonyms: 3β-羟基-5-雄烯-17-酮; 雄素-5-烯-3β-醇-17-酮; 普拉睾酮; DHEA; 去氢表雄酮; 脱氢异雄酮

DATABASE IDS

• Beilstein Number: 2058110
• PubChem SID: 24278369
• CAS Number: 53-43-0
• EC Number: 200-175-5
• MDL Number: MFCD00003613

PROPERTIES

• Purity: ≥99%
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866)rat ... Ar(24208)
• Melting Point: 149-151 °C(lit.)
• Drug Control: Home Office Schedule 4.2regulated under CDSA - not available from Sigma-Aldrich Canada
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: BV8396000
• Safety Statements: 26-36
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Dehydroandrosterone (DHEA) is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.