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trans-Dehydroandrosterone_Molecular_structure_CAS_53-43-0)
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trans-Dehydroandrosterone

Catalog No. D4000 Name Sigma Aldrich
CAS Number 53-43-0 Website http://www.sigmaaldrich.com
M. F. C19H28O2 Telephone 1-800-521-8956
M. W. 288.42442 Fax
Purity ≥99% Email
Storage Chembase ID: 1482

SYNONYMS

Title
反式-脱氢雄甾酮
IUPAC name
(1S,2R,5S,10R,11S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-7-en-14-one
IUPAC Traditional name
dehydroepiandrosterone
Synonyms
3β-羟基-5-雄烯-17-酮
雄素-5-烯-3β-醇-17-酮
普拉睾酮
DHEA
去氢表雄酮
脱氢异雄酮

DATABASE IDS

Beilstein Number 2058110
PubChem SID 24278369
CAS Number 53-43-0
EC Number 200-175-5
MDL Number MFCD00003613

PROPERTIES

Purity ≥99%
Gene Information human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866)rat ... Ar(24208)
Melting Point 149-151 °C(lit.)
Drug Control Home Office Schedule 4.2regulated under CDSA - not available from Sigma-Aldrich Canada
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
RTECS BV8396000
Safety Statements 26-36
German water hazard class 2

DETAILS

Description (English)
Biochem/physiol Actions
Dehydroandrosterone (DHEA) is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.

REFERENCES