3-Bromo-7-nitroindazole

• Catalog No.: B2050
• CAS Number: 74209-34-0
• M. F.: C7H4BrN3O2
• M. W.: 242.02956
• Purity: ≥98% (TLC)

SYNONYMS

• IUPAC name: 3-bromo-7-nitro-1H-indazole
• IUPAC Traditional name: 3-bromo-7-nitroindazole

DATABASE IDS

• MDL Number: MFCD00159910
• CAS Number: 74209-34-0
• PubChem SID: 24278258

PROPERTIES

• Purity: ≥98% (TLC)
• Apperance: light yellow powder
• Solubility: ethanol: soluble25 mg/mL
• Solubility: DMSO: soluble
• GHS Signal Word: Danger
• GHS Hazard statements: H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 60
• Safety Statements: 53-22-36/37/39-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinsons disease. Crystallographic studies show that inhibition of eNOS is due to an induced cascade of conformation changes that ultimately dissociates the tetrahydrobiopterin cofactor from the enzyme.1