Home > Compound List > Product Information
3-Bromo-7-nitroindazole_Molecular_structure_CAS_74209-34-0)
Click picture or here to close

3-Bromo-7-nitroindazole

Catalog No. B2050 Name Sigma Aldrich
CAS Number 74209-34-0 Website http://www.sigmaaldrich.com
M. F. C7H4BrN3O2 Telephone 1-800-521-8956
M. W. 242.02956 Fax
Purity ≥98% (TLC) Email
Storage Chembase ID: 1764

SYNONYMS

IUPAC name
3-bromo-7-nitro-1H-indazole
IUPAC Traditional name
3-bromo-7-nitroindazole

DATABASE IDS

MDL Number MFCD00159910
CAS Number 74209-34-0
PubChem SID 24278258

PROPERTIES

Purity ≥98% (TLC)
Apperance light yellow powder
Solubility ethanol: soluble25 mg/mL
Solubility DMSO: soluble
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H360
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P308 + P313
Risk Statements 60
Safety Statements 53-22-36/37/39-45
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinsons disease. Crystallographic studies show that inhibition of eNOS is due to an induced cascade of conformation changes that ultimately dissociates the tetrahydrobiopterin cofactor from the enzyme.1

REFERENCES