Tetrodotoxin

• Catalog No.: T8024
• CAS Number: 4368-28-9
• M. F.: C11H17N3O8
• M. W.: 319.26798
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (5R,11S,12S,13S,14S)-14-(hydroxymethyl)-3-imino-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1^7,^1^1.0^1,^6]tetradecane-5,9,12,13,14-pentol
• IUPAC Traditional name: (5R,11S,12S,13S,14S)-14-(hydroxymethyl)-3-imino-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1^7,^1^1.0^1,^6]tetradecane-5,9,12,13,14-pentol
• Synonyms: Tarichatoxin; Fugu poison; Maculotoxin; TTX

DATABASE IDS

• Beilstein Number: 49176
• PubChem SID: 24900493
• CAS Number: 4368-28-9
• MDL Number: MFCD00213719
• EC Number: 224-458-8

PROPERTIES

• Purity: ≥98% (HPLC)
• Gene Information: rat ... Scnn1g(24768)
• Apperance: white powder
• Solubility: dilute citrate or acetate buffer: soluble1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.)
• Solubility: strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P260-P264-P280-P284-P302 + P350-P310
• RID/ADR: UN 3462 6.1/PG 1
• Risk Statements: 26/27/28
• RTECS: IO1450000
• Safety Statements: 22-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 1
• German water hazard class: 3
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

DETAILS

Description (English)

Biochem/physiol Actions
Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.